- Cephalosporin moderate spectrum antibiotic1
- Product information sheet
Antibiotic prophylaxis for;
- Open fractures
- Significant wounds that are grossly contaminated and cannot be cleaned
- Traumatic pneumothorax that requires pleural decompression by finger thoracostomy
- Immediate/Severe hypersensitivity to penicillin1
- Closed fractures that do not meet other indication.
- Isolated open fracture of the distal phalanx
- Warfarin Treatment: increased risk of bleeding, monitor INR1
- Mild/Moderate allergy to penicillin or cephalosporins: seek medical advice
- Pregnancy/Breastfeeding: Benefit outweighs risk. Safe to use1
- Renal impairment: dose reduction may be required1,4
- Do not delay transport for the administration of antibiotics
- IM route not to be used1,2
- Rapid infusion of high doses can result in seizures4
- Reconstitute (2 g of powder) with 19 mL of sodium chloride 0.9% or water for injection (WFI)2. Final product concentration is 100 mg/ml.
- Cefazolin should not be administered via the same line as any blood products.
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IV Cefazolin for fractures/prophylaxis
- Adult
- 2 g as a single dose1,2
- Inject slowly over 3 to 5 minutes.
- Paediatric
- 50 mg/kg as a single dose4, maximum 2 g
- Inject slowly over 3 to 5 minutes.
- As above
Common Adverse Effects: diarrhoea, nausea, vomiting, pain and inflammation at injection site, rash, headache1
2 g powder for injection
Storage requirements
Temperature storage requirements: Store below 25°C3
Protect from light3
Reconstituted storage requirements: reconstituted solution is stable for 24 hours at 2-8°C2
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2. Australian Injectable Drug Handbook (AIDH)
3. PI, Cefazolin
4. Cefazolin Monograph – Paediatric, PCH
Document Control
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