UNCONTROLLED WHEN PRINTED
 Introduction
  • Codeine is considered a prodrug, since it is metabolised in vivo to the primary active compounds morphine and codeine-6-glucuronide (C6G). Roughly 5-10% of codeine will be converted to morphine, with the remainder either free, conjugated to form codeine-6-glucuronide (~70%), or converted to norcodeine (~10%) and hydromorphone (~1%).
 Indications
 Contraindications
  • Known hypersensitivity to codeine, aspirin or ibuprofen
  • Asthmatic that is aspirin or NSAID sensitive
  • Active gastrointestinal bleeding or peptic ulceration
  • Pregnant patients
  • Need to drive, operate heavy machinery, or work at heights
  • Constipated patients
 Precautions / Notes
 Preparation
Preparation
 Management
 Weight-based Calculations
 
Clear
 kg 
Mode: 
Weight: 
Cefazolin for fractures/prophylaxis
Presentation: /mL
Calculated dose:  in

Give tablets orally, with water to swallow

Aspirin and Codeine (Aspalgin)

  • 2 tablets every 4 hours to a maximum of 8 tablets per day
  • Dissolve the tablets in a little water before swallowing them
  • Aspalgin can be taken with or without food
  • Not recommended for children under 12 years of age

Ibuprofen 200mg + Codeine 12.8mg (Nurofen Plus)

Adults and children from 12 years:

  • 2 tablets, then 1 or 2 tablets every 4 hours as necessary (maximum 6 tablets in 24 hours).
  • Not for children under 12 years.
 Special Considerations
Presentation
  • Aspalgin (Aspirin 300mg, Codeine 8mg; see Aspirin guideline as well)
  • Ibuprofen 200mg + Codeine 12.8mg (See NSAID guideline as well)
Settings
Current mode:
Extended Care:
Colour assist:

References
References

Document Control


Directorate
Clinical Services

Responsible Manager
Head of Clinical Services

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Issue Date

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