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Introduction
- Hydrocortisone is an adrenocortical steroid that produces an anti-inflammatory process. This inhibits the accumulation of inflammatory cells at inflammation sites, phagocytosis, lysosomal enzyme release and synthesis and/or release of mediators of inflammation. Additionally, it prevents and suppresses cell mediated immune reactions.
Indications
- Patients with known adrenal insufficiency who are symptomatic of adrenal crisis
Contraindications
- Known hypersensitivity
Precautions / Notes
- Hypertension
- The specific method of preparing hydrocortisone for injection can be found here.
- Rarely, patients in adrenal crisis may present with severe psychosis
Management
- Dosage to be given should be in line with patients own management plan.
- In the absence of patients own management plan the following dosages should be followed:
Adult:
- IM:
- 100mg single dose
Paediatric:
- IM:
| Age | Weight | Dosage |
|---|---|---|
| < 6 Months | <7kg | 25mg |
| 6 months to 2 years | 8 - 12 kg | 50mg |
| 3 - 10 years | 13 - 30kg | 75mg |
| >10 years | >30kg | 100mg |
Special Considerations
- Tachycardia
References
References
Presentation
- Vial: 100mg in 2mL (powder for reconstitution)
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