UNCONTROLLED WHEN PRINTED
 Introduction
  • Synthetic pituitary hormone which stimulates uterine muscle contraction1,2
  • Onset of Action: 2-4 mins; Half-life: 3-20 mins; Duration of Action: 30-60 mins1

Product information

 Indications
  • Partial active management of third stage of labour1,2
  • Treatment of postpartum haemorrhage (PPH)1,2
    • Primary: >500mL blood loss within 24 hours of birth
    • Secondary: >500mL blood loss between 24 hours and 12 weeks postpartum
 Contraindications
  • Foetus remaining in uterus, multiple pregnancy must be excluded prior to administration
  • Within 6 hours of vaginal prostaglandins (dinoprostone, gemeprost)2
  • Allergy to oxytocin. Latex allergy may be a risk factor for oxytocin hypersensitivity2
 Precautions / Notes
  • Cardiac Monitoring Required: Administration may result in QT prolongation, changes in blood pressure and heart rate. Caution in patients with long QT syndrome or medications that prolong the QTc interval and patients with pre-existing cardiovascular disease1
  • Controlled cord traction is NOT indicated for SJWA as part of active management of third stage of labour
 Preparation
 Management
 Weight-based Calculations
 
Clear
 kg 
Mode: 
Weight: 
Cefazolin for fractures/prophylaxis
Presentation: /mL
Calculated dose:  in

Partial active management of third stage of labour

IM Injection:

  • 10 IU as a single dose after delivery, approximately 3 minutes post-delivery of baby, when cord stops pulsating.
  • Do not repeat unless treating for associated PPH - see below
Management of confirmed PPH (primary or secondary)


IM Injection:

  • 10 IU as a single dose2
  • Tranexamic acid 1g IV injection to be given in conjunction with oxytocin4
 Special Considerations

Adverse Effects: Nausea, vomiting, headache, arrhythmias

Presentation

OXYTOCIN GH (oxytocin) solution for injection, 10 IU in 1mL Ampoule

Oxytocin GH vial

Storage requirements

Store at 2°C-8 °C. Refrigerate1,3. Do not freeze. Protect from light1.

The unopened product may be stored for up to three (3) months at or below 25°C. Once removed from the refrigerator the product must be discarded if not used, it must not be returned to the refrigerator1.

Settings
Current mode:
Extended Care:
Colour assist:

References

1. Product Information Oxytocin GH® (oxytocin) solution for Injection

2. Australian Medication Handbook, Oxytocin

3. Australian Injectable Drug Handbook v9

4. The Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG). Management of Postpartum Haemorrhage (PPH). 2017


Document Control


Directorate
Clinical Services

Responsible Manager
Head of Clinical Services

Version

Issue Date

Expiry Date

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