Tranexamic Acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis (clot breakdown) by blocking the lysine binding site on plasminogen, competitively inhibiting the activation of plasminogen to plasmin.
Hepatic metabolism with renal excretion.
Adult IV / IO:
Paediatric (<12 years) IV / IO:
The CRASH-2 Collaborators (2010) Effects of Tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 377. 9771: 1096
WOMAN Trial Collaborators. Effects of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in woman with post-partum haemorrhage (WOMAN): an international, randomised, double blind, placebo-controlled trial. Lancet 2017:
389: 2105- 16
Morison JJ, Dubose JJ, Ramussen TE, et al Military application of tranexamic acid in trauma emergency resuscitation (MATTERs) study Ach Surg 2012; 147: 113-19