• Presentation:
    • 1 mg/1 mL (1:1000) ampoule
  • A naturally occurring sympathomimetic agent
  • Causes peripheral vasoconstriction
  • Stimulation of cardiac conduction system causes increased contractions
  • Causes bronchodilation and dilation of blood vessels in muscles
  • IV/IO: Onset 30 seconds, half-life 5 minutes, duration 5-10 minutes
  • IM: Onset 60 seconds, half-life 5 minutes, duration 5-10 minutes

Pharmacology Review

  • Anaphylaxis
  • Life-threatening asthma
  • Cardiac Arrest
  • Post-ROSC
  • Severe croup
  • There are no absolute contraindications to adrenaline
 Precautions / Notes
  • Ischaemic Heart Disease
  • Hypertension
  • Hypovolaemia
  • Do not walk patient pre or post IM adrenaline administration in anaphylaxis - usually a minimum of 1 hour after 1 dose of Adrenaline and 4 hours if more than 1 dose of Adrenaline given
  • If given IV into a peripheral vein, follow each dose with a sodium chloride flush

Cardiac Arrest:

  • Paediatric / Newborn:
    • Dilute 1 mL of 1:1000 adrenaline solution with 9 mL sodium chloride 0.9% to produce 1000 microg in 10 mL (1:10,000)


  • Dilute 1 mL of 1:1000 adrenaline solution with 9 mL sodium chloride 0.9% to produce 1000 microg in 10 mL (1:10,000)
 Weight-based Calculations
IV Adrenaline for Cardiac Arrest
Concentration: 1:
Calculated dose:  in
IV Adrenaline for Post ROSC
Concentration: 1:10,000
Calculated dose:  in
IM Adrenaline for anaphylaxis or life-threatening asthma
Presentation: 1mg:1mL (1:1000)
Calculated dose:  in

Cardiac Arrest


  • 1 mg IV/IO, repeat every 3-5 minutes as clinically indicated

Paediatric / Newborn:

  • 10 microg/kg = 0.1 mL/kg of 1:10,000 adrenaline solution IV/IO, repeat every 3-5 minutes as clinically indicated.
  • Maximum bolus dose 1mg (10mL of 1:10,000 adrenaline solution).
  • Manage hypotension in Post-ROSC patients if BP is slow to rise:
    • The patient is considered hypotensive if Systolic BP is:
      • Adult: < 100mmHg
      • Paediatric: < 80mmHg
  • Titrate Adrenaline as required, to achieve and / or maintain the SBP requirements as listed above.


  • 50 microg (0.5 mL) every 3-5 min as required to maintain systolic blood pressure


  • 1 microg/kg every 3-5 min (maximum bolus 50 microg (0.5 mL)) to maintain systolic blood pressure
Anaphylaxis or life-threatening Asthma


  • 0.5 mg IM into lateral mid-thigh (0.5 mL of 1:1000), repeat every 5 minutes as clinically required

Paediatric > 1 month:

  • 10 microg/kg IM into lateral mid-thigh (0.01 mL of 1:1000) (maximum single dose = 0.5 mg or 0.5 mL), repeat every 5 minutes as clinically required

Infants (>1 month) / Paediatric:

  • Nebulise 5 mg (5 mL of 1:1000) undiluted, repeat after 15 minutes if required (repeat once only, further doses require ASMA consult)
 Special Considerations
  • Tachyarrhythmias, palpitations
  • Hypertension
  • Pupil dilation
  • Tremor
  • Anxiety
1 mg/1 mL (1:1000) ampoule
Current mode:
Extended Care:
Colour assist:


Document Control

Clinical Services

Responsible Manager
Head of Clinical Services


Issue Date

Expiry Date

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