UNCONTROLLED WHEN PRINTED
Introduction
  • A halogenated ether that produces powerful modification of the awareness of pain with an associated light headed sensation.
  • 6-8 breaths/ 1-2 min onset with maximum level after 2-4 minutes.

Pharmacology Review

Indications
  • Pain
Contraindications
  • Patients who are unable to understand or co-operate.
  • Patients with severe renal impairment.
  • Patients with head injury and altered consciousness that prevents co-operation with its use.
  • Hypersensitivity e.g. malignant hyperthermia
Precautions / Notes
  • Use PenthroxTM inhaler with charcoal filter attached
  • Where administration in transit is necessary, the rear extractor fan must be used and the rear facing seat should remain vacant
  • Instruct the patient to breathe in through their mouth and out through their mouth via the inhaler. For maximum effect cover the air dilutor hole.
  • Initial breath is strong and may cause the patient to cough, so advise to take gently
  • Watch for drowsiness
  • If oxygen is required deliver separately
  • Place in a sealed plastic bag when not in use
Management
  • Initial dose: 1 x 3ml ampoule.
  • Subsequent dose: 1 x 3ml ampoule after 15 minutes if still in severe pain or pain returns, once only.
  • Maximum dose: 6ml/24 hrs or 15ml (5 doses) per week.
Special Considerations
  • Lightheaded
  • Dizziness
  • Drowsy
  • Nausea
  • Malignant hyperthermia

References
References
Presentation
3mL ampoule for inhalation via Penthrox inhaler

MXFBottle

Methoxyflurane

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Directorate
Clinical Services

Responsible Manager
Head of Clinical Services

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