UNCONTROLLED WHEN PRINTED
Introduction
  • Paracetamol is a p-aminophenol derivative that exhibits analgesic and antipyretic activity.
  • Delayed onset of action with peak effect via oral route achieved in ≥ 60 minutes.

Pharmacology Review

Indications
  • Mild to moderate pain
    • For example, headache, sprain/strain, toothache, etc.
    • As a component of a multimodal analgesic regime.
Contraindications
  • Known hypersensitivity to Paracetamol.
  • Do not give if patient has had Paracetamol in the preceding 4 hours.
  • Cannot exceed the maximum allowed single dose or exceed the maximum allowed paracetamol daily dose (24hrs).
Precautions / Notes
  • There is no evidence that fever itself worsens the course of an illness. The primary goal should be to improve overall comfort [1]
  • SJA do not support the use of paracetamol in infants < 6 months.
  • 20 ml Paracetamol suspension bottle is single patient use only.
  • Only used enteral syringe/dropper with suspension [2]
Management

Adult:

  • 500mg tablet; oral administration of 500-1000mg (1-2 tablets)
  • Max single dose 1000mg
  • Max dose not to exceed 4000mg over a 24 hour period

Paediatric:

  • 100mg/ml (oral suspension)
  • 6 months - 12 years old: 15mg/kg
  • Repeat every 4 to 6 hours
  • Maximum daily dose is 60mg/kg in divided doses of 15mg/kg (not to exceed 4000mg), over a 24 hour period
Special Considerations
  • Nil known at therapeutic doses.

References
References
Presentation
  • 500mg white tablets
  • 100mg/ml (2000mg/20ml) suspension

Panadol

Panadol Suspension Box

Panadol Suspension

Further reading:

Janice E. Sullivan, H. C. (n.d.). Clinical Report - Fever and Antipyretic use in Children. The American Academy of Pediatrics.

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