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Introduction
  • Hydrocortisone is an adrenocortical steroid that produces an anti-inflammatory process. This inhibits the accumulation of inflammatory cells at inflammation sites, phagocytosis, lysosomal enzyme release and synthesis and/or release of mediators of inflammation. Additionally, it prevents and suppresses cell mediated immune reactions.
Indications
  • Patients with known adrenal insufficiency who are symptomatic of adrenal crisis
Contraindications
  • Known hypersensitivity
Precautions / Notes
  • Hypertension
  • The specific method of preparing hydrocortisone for injection can be found here.
  • Rarely, patients in adrenal crisis may present with severe psychosis
Management
  • Dosage to be given should be in line with patients own management plan.
  • In the absence of patients own management plan the following dosages should be followed:

Adult:

  • IM: 
    • 100mg single dose

Paediatric:

  • IM:
Age Weight Dosage
< 6 Months <7kg 25mg
6 months to 2 years 8 - 12 kg 50mg
3 - 10 years 13 - 30kg 75mg
>10 years >30kg 100mg
Special Considerations
  • Tachycardia

References
References
Presentation
  • Vial: 100mg in 2mL (powder for reconstitution)

hydrocortisone

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Head of Clinical Services

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