Compounded medication produced for pre-drawn use in maintaining sedation post RSI.
- A narcotic analgesic acting on CNS by binding with opioid receptors
- Also combines to cause respiratory depression, vasodilation, decreases gag reflex and slows AV node conduction
- A water-soluble benzodiazepine that has anxiolytic, sedative and anticonvulsive characteristics. This is due to its bonding with receptors in the CNS; its action to increase the inhibitory effect of the g-aminobutyric acid (GABA) neurotransmitter
on the GABA receptors and subsequent membrane threshold.
- Midazolam is lipid-soluble in physiological pH and it reaches the CNS quickly