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Introduction

Aspirin has the following pharmacological actions:

  • Analgesic
  • Antipyretic
  • Anti-inflammatory
  • Anti-platelet aggregation agent

Reduces mortality significantly in Acute Myocardial Infarction by minimising platelet aggregation and thrombus formation in order to retard the progression of coronary artery thrombosis.

Pharmacology Review

Indications
  • Chest pain / discomfort of presumed cardiac origin.
Contraindications
  • Known hypersensitivity to aspirin / salicylates.
  • Children < 12 years of age.
Precautions / Notes
  • Actively bleeding peptic ulcers.
  • Suspected AAA.
  • Aspirin / salicylate-sensitive asthmatics
Management
  • 300mg oral administration, preferably chewed.
  • Administered even if patient has taken aspirin that day or on anticoagulants.
Special Considerations
  • Heart burn, nausea, GI bleeding.
  • Increased bleeding time.
  • Anaphylactic reaction (some patients, especially asthmatics) exhibit notable sensitivity to aspirin, which may provoke various hypersensitivity / allergic reactions)

References
References
Presentation
300mg white tablet
Disprin
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