UNCONTROLLED WHEN PRINTED
Introduction
  • A hyperglycaemic agent that converts stored liver glycogen to glucose to increase blood glucose concentration.
  • Onset 4-7 minutes, duration 10-30 minutes.

Pharmacology Review

Indications

For demonstrated hypoglycaemia where oral glucose cannot be administered and IV access cannot be obtained in a safe and timely manner.

  • Altered conscious state in a known diabetic or of otherwise unknown cause where blood glucose level is below 4mmol/L.
Contraindications
  • Hypersensitivity.
  • Known pheochromocytoma
Precautions / Notes
  • Glucagon is effective in treating hypoglycaemia only if sufficient liver glycogen is present (eg: it does not work on alcohol or anorexia induced hypoglycaemia).
  • Even if fully recovered, patients should be encouraged to be transported to a medical facility to ensure effective follow up and review.
Management

Intramuscular injection into deltoid muscle or mid-lateral thigh

Adult:

  • 1mg in 1ml IM.
  • Repeat IM Glucagon after 10 minutes if unable to obtain IV access and patient still has inadequate GCS and blood glucose level.

Paediatric:

  • <5 years: 0.5mg in 0.5ml
  • 6-12 years: 1.0mg in 1.0ml
  • Single dose only
Special Considerations
  • Nausea/vomiting
  • Gastric pain
  • Transient rise of blood pressure for patients taking beta blockers.

References
References
Presentation
1mg in 1ml vial, accompanied by diluent for injection.
Glucagon
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