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Introduction

Glucagon is a 29-amino-acid polypeptide hormone secreted by alpha cells of islets of Langerhans in response to hypoglycemia.

Uses within SJA

For demonstrated hypoglycaemia where oral glucose cannot be administered and IV access cannot be obtained in a safe and timely manner.

Pharmacokinetics

It is bound in the Liver, Kidneys and other organs, and is metabolised in the blood and organs

Pharmacodynamics

Desired Effects

Glucagon acts primarily by stimulating hepatic glycogenolysis and gluconeogenesis and inhibiting glycogen synthesis, elevating the blood concentration of glucose.

Side Effects

  • Nausea/vomiting
  • Gastric pain
  • Transient rise of blood pressure for patients taking beta blockers.

Duration of Action

  • Onset 4–7 minutes
  • Duration 10–30 minutes

Other Drug Interactions

No significant drug interactions are reported.

 

 


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