Lignocaine is an amide-type local anaesthetic that prevents the initiation and propagation of nerve impulses. It also has antidysrhythmic properties because it stabilises all potentially excitable membranes including the conduction system of the heart.
Rapid 5-10 minutes and duration of nerve blockade is 1-1.5 hours.
After absorption into the general circulation or after IV injection, the drug is redistributed rapidly to tissues, especially the heart.
In the liver Excretion: Via the kidneys
Local anaesthesia by topical, infiltration, nerve block, epidural, spinal, ophthalmic and intravenous regional anaesthesia routes.
Duration of Action
The elimination half-life is 90-120 minutes.
Other anti-dysrhythmics, phenytoin and alcohol may potentiate the cardiovascular effects of lignocaine.
St John WA