A water-soluble benzodiazepine that has anxiolytic, sedative and anticonvulsive characteristics. These are based on its bond with receptors in the central nervous system; its action to increase the inhibitory effect of the g-aminobutyric acid (GABA)
neurotransmitter on the GABA receptors and subsequent membrane threshold.
Midazolam is lipid-soluble in physiological pH and it reaches the central nervous system quickly.
Aafter IM injection, absorption from the muscle tissue is rapid and complete. Maximum plasma concentrations are reached within 30 minutes. The absolute bioavailability after IM injections is over 90%.
60-80% of the dose is excreted in urine as conjugates
Midazolam is a very short-acting benzodiazepine, with powerful anxiolytic, sedative-hypnotic and muscle relaxant effects caused by facilitation of GABA-mediated CNS inhibitory pathways.
It has rapid onset of actions and, because of rapid metabolic transformation, short duration.
Anterograde and retrograde amnesia.
Duration of Action:
Very short acting.
1 to 3 hours
Other Drug Interactions
Midazolam has additive CNS-depressant effects with all other CNS depressants.
Default Author St John WA
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