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Introduction

Sympathomimetic; a short acting synthetic beta 2 adreno-receptor stimulant that causes relaxation of bronchial smooth muscle (bronchodilation).

Pharmacokinetics

Onset

  • 5-15 minutes

Absorption

  • Inhaled

Metabolism

  • In the liver

Excretion

  • In the kidneys

Pharmacodynamics

Desired Effects

  • Relaxation of bronchial smooth muscle

Side Effects

  • Muscle tremor
  • Tachycardia

Duration of Action

  • Peak effect within 1-2 hours
  • Total duration of action 3-6 hours.

Other Drug Interactions

  • Concomitant therapy with other sympathomimetic amines will cause excessive sympathetic stimulation (tremor, tachycardia).
  • Beta-blockers antagonise the effects of B2-agonists and may precipitate asthma, so they are contraindicated.
  • Hypokalaemia resulting from B2-agonists therapy may be potentiated by xanthine derivatives, steroids or diuretics; potassium levels should be monitored.
  • Antidepressant drugs may potentiate cardiovascular effects.

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